Sergio Ramos expected to return on Wednesday night.
The Blues secured a 1-1 draw at Estadio Alfredo Di Stefano on April 28.
Thomas Tuchel believes he could operate with a false nine in order to restrict the Spaniard’s effectiveness.
The German coach has not yet confirmed his approach to go with if the Real Madrid captain makes a possible return at Stamford Bridge.
“If we play with no striker at all and Ramos has nothing to fight then that can also be a solution. I have not made my mind up yet,” he told Chelsea’s official website.
“It’s another challenge because he is the leader of their group and he is the guy to give a lot of solutions to any questions that we will hopefully ask them.
“We will wait and see who is in good shape and good form, what shape we play and where we try to hurt them.
“I’m not too sure if they will play again with five or go back to four [in defence] so there are many questions, but we don’t need the answers now. It’s enough if we have them on Wednesday.”